Meeting Banner
Abstract #1667

Reducing Protocol Variability Enhances Predictive Performance of Breast MRI Biomarkers in a Multicenter Clinical Trial

Pouya Metanat1, Natsuko Onishi1, Wen Li1, Jessica Gibbs1, Lisa J Wilmes1, Nu Le1, Matthew Gibbons1, Teffany Joy Bareng1, Margarita Watkins1, Elissa R Price1, Bonnie N Joe1, John Kornak1, Christina Yau2, Denise Wolf3, Mark Magbanua3, Barbara LeStage4, ISPY2 Imaging Working Group3, ISPY2 Investigator Network5, Jane Perlmutter6, Douglas Yee7, W. Fraser Symmans8, Hope S Rugo3, Claudine Isaacs9, Rebecca A. Shatsky10, Angela DeMichelle11, Laura Johanna van 't Veer3, Laura J Esserman3, and Nola M Hylton1
1Radiology and biomedical imaging, University of California, San Francisco, San Francisco, CA, United States, 2Buck Institute, Novato, CA, United States, 3University of California, San Francisco, San Francisco, CA, United States, 4Alliance for Clinical Trials in Oncology, Chicago, IL, United States, 5Quantum Leap Healthcare, San Francisco, CA, United States, 6Gemini Group, Ann Arbor, MI, United States, 7University of Minnesota, Minneapolis, MN, United States, 8MD Anderson, Houston, TX, United States, 9Georgetown University Medical Center, Washington, DC, United States, 10University of California, San Diego, San Diego, CA, United States, 11University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Quantitative Imaging, Breast, DCE MRI, FTV, Clinical Trial, Protocol adherence

Motivation: Variability in imaging protocols can reduce the predictive accuracy of biomarkers like FTV in multicenter trials. This study evaluates whether stricter DCE-MRI protocol adherence improves FTV’s predictive power for pCR.

Goal(s): To assess the impact of revised DCE-MRI protocols on FTV’s accuracy for pCR in the I-SPY 2 trial.

Approach: MRI data from 2,118 participants were analyzed, comparing AUCs for pCR prediction pre- and post-2021 protocol update, with acquisition duration consistency assessed via CV.

Results: Post-update, AUC for FTV increased from 0.686 to 0.742, with acquisition CV consistently below 10%, indicating stable imaging conditions and enhanced predictive reliability.

Impact: Enforcing stricter adherence to MRI protocol improved FTV’s predictive accuracy for identifying pathological complete response (pCR) in breast cancer neoadjuvant therapy, increasing reliability and data consistency within the I-SPY 2 trial’s multicenter framework.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords