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Abstract #1669

Longitudinal Validation of Quantitative T1 MRI Measurements: A Six-Year Multi-Site Analysis Using the ISMRM/NIST Reference System

Jessica A. Martinez1,2, Aaron McCann3, Julia Sharp4, Cormac McGrath3, and Kathryn E. Keenan1
1Physical Measurement Laboratory, National Institute of Standards and Technology (NIST), Boulder, CO, United States, 2Department of Physics, University of Colorado Boulder, Boulder, CO, United States, 3Radiological Sciences and Imaging, Regional Medical Physics Service, Belfast Health & Social Care Trust, Belfast, Northern Ireland, United Kingdom, 4National Institute of Standards and Technology (NIST), Boulder, CO, United States

Synopsis

Keywords: Quantitative Imaging, Reproductive, Phantom, T1

Motivation: To assess the reliability of quantitative MRI T1 measurements over time and across multiple MRI centers.

Goal(s): To evaluate the consistency of T1 relaxometry across eleven centers over six years using the ISMRM/NIST phantom.

Approach: Inversion-recovery T1 mapping was conducted to assess intra- and inter-site variability, comparing results to reference standards.

Results: T1 values consistently remained within ±5% of reference standards across sites and time, suggesting reliable, stable measurements. This supports the use of quantitative T1 mapping in routine clinical settings and multi-center studies for disease monitoring and treatment assessment.

Impact: This study demonstrates that standardized T1 relaxometry protocols yield consistent and reproducible measurements of the ISMRM/NIST phantom across multiple MRI centers over six years, supporting the clinical applicability of quantitative MRI for multi-center disease monitoring and treatment evaluation.

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