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Abstract #1671

A T1-independent sequence enables accurate quantitative proton density mapping from standard MRI protocols in human brain

Kiarash Jalali1, Peter Seres2, and Alan Wilman1,2
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Proton Density mapping, Relaxometry

Motivation: Quantitative Proton Density (qPD) mapping can track Multiple Sclerosis (MS) progression, but current methods are limited by inaccurate cerebrospinal fluid (CSF) T1 values in standard protocols.

Goal(s): To develop accurate CSF-referenced water content mapping from standard brain MRI by implementing a T1-independent sequence.

Approach: A rapid T1-independent Echo Planar Imaging sequence was added to standard 3T MRI protocols. Correction factors for PD maps were developed from Multi-Echo Gradient Echo and Turbo Spin Echo sequences.

Results: Accurate qPD mapping was enabled by correcting suppressed CSF values, confirmed through phantom studies and testing in MS and healthy subjects.

Impact: A rapid (20 s) T1-independent MRI sequence allows quantification of accurate CSF-referenced brain water content when combined with common protocols, enabling an additional quantitative parameter for examining MS disease progression.

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