Abstract #1677

Quantitative microstructural mapping based on time-dependent diffusion MRI for predicting CEA levels in rectal cancer

Yanwan Li¹, Xiaoli Chen¹, Xiaolei Dong¹, Siqi Yi¹, Meining Chen², and Peng Zhou¹

¹Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China, ²MR Research Collaboration, Siemens Healthineers Ltd., Chengdu, China, Chengdu, China

Synopsis

Keywords: Quantitative Imaging, Cancer, Oscillating gradient spin-echo, Carcinoembryonic antigen

Motivation: Carcinoembryonic antigen (CEA) levels are an established marker for rectal cancer aggressiveness, yet current imaging methods do not reliably predict CEA status or associated metastatic potential.

Goal(s): This study aims to evaluate the use of time-dependent diffusion MRI (td-dMRI) for predicting elevated CEA levels in rectal cancer, offering a non-invasive assessment method.

Approach: We applied td-dMRI to quantify microstructural parameters, such as cell diameter and cellularity, in rectal cancer patients, differentiating between CEA-positive and CEA-negative cases.

Results: Findings showed that higher cell diameter and lower cellularity are significantly associated with elevated CEA levels, achieving an AUC of 0.760 when combined.

Impact: Microstructural parameters based on td-dMRI have the potential to reflect elevated CEA levels, thereby serving as predictors of the proliferative and metastatic capabilities of rectal cancer.

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