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Abstract #1682

Multiple Parameters from Ultrafast Dynamic Contrast-enhanced MRI to Differentiate HER2-Zero, -Low, and -Positive Breast Cancer

Ying Cao1, Xiaoxia Wang2, Yao Huang1, Huifang Chen2, Ting Yin3, and Jiuquan Zhang2
1School of Medicine, Chongqing University, Chongqing, China, 2Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China, 3MR Research Collaboration, Siemens Healthineers, Chengdu, China

Synopsis

Keywords: Quantitative Imaging, Cancer, Diagnosis/Prediction

Motivation: Accurate differentiation of human epidermal growth factor receptor 2 (HER2) expression status in breast cancer (BC) is essential for selecting appropriate targeted therapies. Current diagnostic methods have limitations in identifying low HER2 expression levels, necessitating more efficient, non-invasive techniques.

Goal(s): To evaluate the feasibility of using ultrafast dynamic contrast-enhanced MRI (UF-DCE MRI) to distinguish HER2 expression statuses in BC.

Approach: 398 histopathologically-confirmed BC patients underwent UF-DCE MRI. Five UF-DCE MRI-derived parameters were analyzed to assess their diagnostic performance.

Results: UF-DCE MRI parameters showed significant differences between HER2-Zero, HER2-Low, and HER2-Positive subtypes, though diagnostic performance was moderate.

Impact: This research demonstrates that UF-DCE MRI could provide a non-invasive method for distinguishing HER2 expression levels in BC, aiding in selecting appropriate therapies. It has the potential to improve personalized treatment approaches and influence future clinical practice in HER2-targeted therapies.

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