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Abstract #1691

Resolving partial-volume effects in the brain with multidimensional T1xT2 MRI

Nikos Priovoulos1, Hongyan Liu1, Dan Benjamini2, Amy F D Howard1,3, Aaron T Hess1, and Karla L Miller1
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Multiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, Baltimore, MD, United States, 3Department of Bioengineering, Imperial College London, London, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging

Motivation: Despite much work, quantifying relaxation of multiple tissue types within-voxel still evades MRI relaxometry.

Goal(s): To compare 2D-T1xT2 spectra against 1D-T1 and 1D-T2 in separating tissue type within-voxel.

Approach: The relaxometry spectral fitting methods were compared following in-vivo measurements covering a TExTI grid.

Results: The 2D-T1xT2 distributions could better disentangle tissue-types in ground-truth ROIs compared to 1D (T1 or T2) spectra. Voxel-wise fits produced anatomically-meaningful components and volume-fractions. Voxels with multiple spectral peaks (e.g. maximum peaks at typical T1/T2 of gray matter and cerebrospinal fluid) were identified at the appropriate anatomical borderline, suggesting that within-voxel partial-voluming is truly reflected by these peaks.


Impact: Resolution limits mean that multiple tissue types are frequently captured within a single MRI voxel. We demonstrate the ability to separate these compartments with 2D-T1xT2 approaches. Measuring multi-dimensional spectra may enable better modelling of the biological sources of MRI contrasts.

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Keywords