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Abstract #1703

Relaxometry to get the right values, or getting the right data for the patient: a false dilemma

Maarten Naeyaert1, Peter Van Schuerbeek1, Manon Marie Roose1, Thomas Janssens2, and Hubert Raeymaekers1
1Department of Radiology, Universitair Ziekenhuis Brussel, Jette, Belgium, 2Siemens Healthineers NV, Groot Bijgaarden, Belgium

Synopsis

Keywords: Quantitative Imaging, MR Fingerprinting/Synthetic MR

Motivation: Quantitative MRI claims to give reproducible values, but different systems, techniques and settings influence the results.

Goal(s): To find how the accuracies of different relaxometry sequences compare to each other, and determine the implications for the future of quantitative MRI.

Approach: T1 and T2 were determined in a NIST-calibrated phantom using the variable TE, variable TI, multi-delay multi-echo, 3D-QALAS, MR fingerprinting, and MP2RAGE techniques.

Results: Variable TI and MP2RAGE perform very similar, and estimate T1 within 6%. MRF estimates T1 and T2 within 10%, while MDME and 3D-QALAS have lower accuracy and precision. However, MDME and 3D-QALAS see more use in the clinic.

Impact: Currently no simultaneous T1-T2-relaxometry technique exists which is both accurate in phantoms and integrated in the clinic. Clinical usefulness, advanced physical system models, and high-quality phantoms should all be integrated into the development of quantitative relaxometry techniques to achieve this.

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