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Abstract #1722

Amide Proton Transfer-weighted MRI in Predicting Histologic Grade of Clear Cell Renal Cell Carcinom

Yun Xu1, Qingxuan wan1, Peng WU2, Aijun Shen1, and peijun Wang1
1Tongji Hospital of Tongji University, Shanghai, China, 2Philips Healthcare, Shanghai, China

Synopsis

Keywords: fMRI Analysis, CEST / APT / NOE

Motivation: The potential value of APTw imaging for assessing ccRCC grade has not yet been established.

Goal(s): This study aims to investigate the potential of amide proton transfer-weighted (APTw) MRI in evaluating the grade of clear cell renal cell carcinoma and to evaluate whether APTw MRI can add value to diffusion-weighted imaging (DWI) and mDixon MRI.

Approach: A total of 48 patients with ccRCC (10 high-grade) were included. ROC curve analysis was performed to evaluate the diagnostic performance of quantitative imaging parameters.

Results: The results show that APTw is a potential indicator for preoperative prediction of ccRCC pathologic grade.

Impact: APTwmean, APTwmax, APTwSD, and ADCmin values are potential indicators for preoperative prediction of ccRCC pathological grading. APTwSD showed greater diagnostic performance.

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Keywords