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Abstract #1724

Multimodal Metabolic Imaging of Resistance to Antiandrogens in Prostate Cancer Patient-Derived Xenografts

Jose S. Enriquez1,2, Prasanta Dutta1, Muxin Wang1,2, Peter Shepherd3, Aldo T. Morales1, Julia R. Zickus1,2, Onder Otlu4, Jenny Han1, Estefania Labanca3, Daniel E. Frigo1,2, Federica Pisaneschi2,4, and Pratip K. Bhattacharya1,2
1Cancer System Imaging, UT MD Anderson Cancer Center, Houston, TX, United States, 2UT MD Anderson Cancer Center UT Health Science Center Houston Graduate School of Biomedical Sciences, Houston, TX, United States, 3Genitourinary Medical Oncology, UT MD Anderson Cancer Center, Houston, TX, United States, 4IMM-Center for Translational Cancer Research, UT Health Houston, Houston, TX, United States

Synopsis

Keywords: Prostate, Multimodal, Metabolic Imaging, Prostate Cancer, Hyperpolarized MR

Motivation: Many advanced prostate cancer (PCa) patients receiving anti-androgens (Enzalutamide) as the first line of treatment, develop resistance which relapses into metastatic castrate-resistant PCa (mCRPC) with an alarming low survival rate of only 28%.

Goal(s): The overarching goal of this research is thus to develop personalized metabolic imaging modality to target treatment strategies of different metabolic sub-types of PCa.

Approach: By targeting pyruvate-to-lactate metabolism by hyperpolarized [1-13C]-pyruvate MR and fatty acid oxidation by 18F-FPIA PET.

Results: HP-MR is effective in classifying resistant and sensitive PCa and interrogating an MCT1 inhibitor, Syrosingopine, that is effective in sensitizing a resistant phenotype.

Impact: The research described has the potential to lead practice-changing recommendations by detecting therapeutic efficacy earlier and changing the patient to a different therapeutic regiment. This research also has the potential to recommend combination therapy in the clinic to resistant patients.

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