Keywords: Prostate, Prostate, PI-RADS 3,Clinically significant prostate cancer
Motivation: The positive rate of PI-RADS 3 biopsy was low,Moreover, many Gleason 3+3 lesions, due to repeated biopsies, ultimately opt for more aggressive treatment in a short time.
Goal(s): To evaluate the ability of Prostate-Specific Antigen Density (PSAD) , Amide Proton Transfer (APT) and Intravoxel Incoherent Motion (IVIM) in risk stratification of PI-RADS 3 lesions .
Approach: PSAD (PSA/prostate volume) was calculated with prostate volume. Conventional MRI sequences and APT, IVIM imaging were acquired in 3T MR.
Results: PSAD, APT, and IVIM can further effectively stratify the risk of PI-RADS 3 lesions , potentially reducing unnecessary biopsies . Among these, APT exhibited the highest Area Under the Curve.
Impact: PSAD, APT, and IVIM can distinguish clinically significant prostate cancer from non-clinically significant prostate cancer and benign prostatic hyperplasia in PI-RADS 3 lesions of the transitional zone, thereby reducing unnecessary biopsies.
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