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Abstract #1731

Rapid Monitoring of Glycogen Dynamics: MRS-based T1 and T2 Water Relaxation Times as potential surrogates for 13C-MRS

Florian Haans1, Julian Mevenkamp1, Kim Brouwers1, Vera Schrauwen-Hinderling1, and Mijke Buitinga1,2
1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Department of Nutrition & Movement Sciences, Maastricht University, Maastricht, Netherlands

Synopsis

Keywords: Liver, Spectroscopy, Glycogen, relaxation

Motivation: The limited temporal resolution and accessibility of 13C-MRS restrict studying rapid glycogen changes. Since glycogen influences water relaxation times by binding water, water relaxation measurements by 1H-MRS may offer a faster alternative to monitor glycogen content dynamically.

Goal(s): This study assesses water relaxation time measurements using 1H-MRS as a surrogate for glycogen.

Approach: Water T1 and T2 relaxation times were measured with 1H-MRS in phantoms and in vivo. Glycogen was quantified using 13C-MRS. Measurements were performed before and after ingestion of 75g of glucose.

Results: Water T1 correlated better with glycogen levels and detected post-glucose dynamic changes in liver and muscle tissue.

Impact: We demonstrate that water T1 relaxation time measured by 1H-MRS could provide a faster, accessible alternative to 13C-MRS for glycogen detection, enabling real-time, simultaneous measurement of glycogen dynamics across multiple organs.

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Keywords