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Abstract #1735

Preliminary results from Improved Prediction in Ovarian Cancer Surgery [IMPROCAS]: a Hyperpolarized 13C Clinical Trial

Malene Aastrup1, Uffe Kjærgaard1, Esben Søvnsø Szocska Hansen1, Nichlas Vous Christensen1, Lotte Bonde Bertelsen1, Ferdia Gallagher2, Steffen Ringgaard 1, Katrine Fuglsang3, Kirsten Bouchelouche4, Ole Mogensen3, Christoffer Laustsen1, and Jack J Miller1,5
1Department of clinical medicine, Aarhus University, The MR Research Centre, Aarhus N, Denmark, 2Department of Radiology, Cambridge University, Cambridge, United Kingdom, 3Department of Gynaecology and Gynaecological Surgery, Aarhus University Hospital, Aarhus N, Denmark, 4Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus N, Denmark, 5Department of Nuclear Medicine & PET Centre, Aarhus University, Aarhus N, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Cancer, Hyperpolarized MR (Non‐Gas), Ovarian cancer, Multi‐Contrast, FDG-PET/CT

Motivation: The most important determinant of survival for ovarian cancer patients is complete surgical resection, but current preoperative imaging methods cannot predict this accurately. Hyperpolarized 13C MRI enables imaging of cancer metabolism, potentially improving diagnostics of adnexal masses.

Goal(s): To explore the utility of Hyperpolarized 13C MRI to detect metabolic changes in adnexal masses comparred with 18F-FDG-PET/CT.

Approach: Presenting the first two cases from the IMPROCAS trial, where 18FDG-PET/CT and 1H/13C MRI were performed.

Results: In patient 1, an 18F-FDG-avid ovarian mass did not produce increased 13C-lactate and was histopathologically benign. In patient 2, the primary ovarian tumour had 18F-FDG-uptake and increased lactate production.

Impact: This is the first presentation of a direct FDG/Hyperpolarized 13C pyruvate comparison of histopathologically benign and malign ovarian masses and highlights the metabolic distinction of the techniques and their synergistic utility. This is of broad interest in oncology.

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