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Abstract #1739

Optimized methods for robust calculation of chemical shifts in hyperpolarized 129Xe MR spectroscopy

Seth Lee1, Andrew McHorse1, Anna Costelle1, and Bastiaan Driehuys1,2,3
1Medical Physics Graduate Program, Duke University, Durham, NC, United States, 2Department of Radiology, Duke University, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, Durham, NC, United States

Synopsis

Keywords: Lung, Spectroscopy, 129Xe, chemical shift measurement

Motivation: Hyperpolarized 129Xe RBC chemical shift is an increasingly important biomarker for lung disease, but the robustness of its calculation has not been investigated.

Goal(s): The aim of this study is to identify a more accurate and optimal method of calculating RBC chemical shift in 129Xe MRS compared to standard practice.

Approach: We investigated two approaches for the 0-ppm 129Xe gas-phase reference frequency: 1) the incidental gas signal arising during RBC excitation and 2) a dedicated gas excitation.

Results: RBC shifts calculated using dedicated gas-phase references were found to be more repeatable and potentially more accurate than standard incidental references.

Impact: Using dedicated 129Xe gas-phase excitation to calculate the 0-ppm reference frequency yielded more repeatable and accurate quantifications of the RBC shift than standard practice, enabling more robust characterization of lung disease via 129Xe MRS.

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