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Abstract #1745

Diagnostic Performance of PDFF, MRE, and T1 Mapping for Detection of NASH and streamline MRI protocol

Xin Lu1, Yuyao Xiao2, and Chun Yang2
1Shanghai Geriatric Medical Center, Shanghai, China, 2Zhongshan Hospital Fudan University, Shanghai, China

Synopsis

Keywords: Liver, Liver

Motivation: NASH identification is significant, however lacking reliable and concise preoperative assessment.

Goal(s): To evaluate performance of MRE, MRI-PDFF and T1 mapping in diagnosing NASH and establish a streamlined MRI protocol to diagnosis NASH more efficiently.

Approach: Patients with suspected or diagnosed NAFLD who had liver biopsy and multiparametric MRI/MRE within 30 days were enrolled. Imaging parameters (LSM, PDFF, R2*, T1 mapping) were compared across NAFLD stages using appropriate statistical tests. Prediction models for NASH diagnosis were developed using combinations of these parameters.

Results: The two-parameter model using PDFF and MRE-based LSM is sufficient for a streamlined non-contrast liver imaging protocol to NASH diagnosis.

Impact: As an active form of NAFLD, NASH can accelerate fibrosis, leading to end-stage liver disease and hepatocellular carcinoma. A streamlined non-contrast liver imaging protocol consisting of PDFF and MRE-based LSM can diagnose NASH satisfactorily and cost-effectively.

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