Abstract #1752

Placental morphology assessment in growth-restricted fetuses using MRI

Dana Schonberger^1,2, Tal Shemesh^1,2,3, Daphna Link-Sourani^1,4, Aviad Rabinowich^1,5,6, Bella Specktor-Fadida⁷, Liat Ben-Sira^5,6, Leo Joskowicz⁸, Liran Hiersch⁹, Gil Marom¹⁰, and Dafna Ben Bashat^1,3,5

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ³Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁴Human MRI Research Center, Technion, Haifa, Israel, ⁵Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁶Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Faculty of Social Welfare and Health Sciences, Department of Medical Imaging Sciences, University of Haifa, Haifa, Israel, ⁸School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, ⁹Department of Maternal-Fetal Medicine and High Risk Pregnancy Outpatient clinic, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ¹⁰School of Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Placenta, Placenta, Fetal, Prenatal, Morphology, Fetal Growth Restriction

Motivation: Current imaging methods for placental assessment are challenging and yield inconsistent results in evaluating fetal growth restriction (FGR).

Goal(s): To assess placental morphology features based on structural MRI in appropriate-for-gestational-age (AGA) and FGR fetuses.

Approach: Data of 141 fetuses (104 AGA, 37 FGR) were included, and morphological features including umbilical-cord insertion location, placental volume, shape features and maternal and fetal sides surface areas, were extracted.

Results: FGR placentas showed more marginal cord insertions, reduced volumes and diameters, and reduced maternal surfaces and maternal-to-total surface ratios. Morphological analysis may provide a simple tool to identify fetuses at risk for FGR.

Impact: Placental morphology features based on structural MRI, including umbilical cord insertion site, placental volume, and maternal surface areas, demonstrated significant alterations in growth-restricted fetuses, and may provide a simple tool to improve identification of fetuses at risk for FGR.

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