Meeting Banner
Abstract #1761

Noninvasive cardiovascular MRI pressure-volume loops reveal impact of left bundle branch block beyond impaired ejection fraction

Lukas Öman1, Per M Arvidsson2, Felicia Seemann3, and Björn Wieslander1
1Department of Clinical Physiology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Department of Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden, 3Cardiovascular Branch, Division of Intramural Research, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Heart Failure, Cardiovascular, Pressure-volume loop

Motivation: Left bundle branch block (LBBB) exacerbates heart failure through left ventricular (LV) dyssynchrony. Hemodynamic understanding of LBBB could potentially be improved using Pressure-Volume (PV) loop analysis.

Goal(s): We aimed to compare LBBB patients to controls matched for age-, sex-, and ejection fraction using a method to calculate PV loops noninvasively using cardiovascular magnetic resonance short-axis cine images and brachial blood pressure.

Approach: We compared noninvasive PV loops in LBBB patients (n=40) and matched controls (n=40).

Results: Noninvasive PV loops revealed 22 % lower contractility in LBBB patients compared with controls (p=0.002) despite matching for LV ejection fraction.

Impact: Cardiovascular magnetic resonance-derived noninvasive PV loops reveal lower contractility in LBBB, independently of the conventional measure of left ventricular ejection fraction. Therefore, PV loop derived contractility could potentially help assess and optimize treatment of LBBB using cardiac resynchronization therapy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords