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Abstract #1764

Cardiac MRI Reveals Matured Pluripotent Stem Cell-Derived Cardiomyocyte Therapy Attenuates Adverse Remodelling in Guinea Pigs

Moses Cook1, Jennifer Barry2, Beiping Qiang3, Melissa Larsen2, Bilgehan Ozcan3, Colleen Bailey2, Lorena Cortes3, Wahiba Dhahri3, Tamilla Valdman Sadikov3, Michael Laflamme3, and Graham Wright1,4
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3McEwen Stem Cell Institute, University Health Network, Toronto, ON, Canada, 4Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Synopsis

Keywords: Myocardium, High-Field MRI, Stem cells, regenerative medicine

Motivation: Assessing the therapeutic integration and contractile changes using matured pluripotent stem cell-derived cardiomyocytes (PSC-CMs) for myocardial infarction (MI) remains challenging. Current limitations in in vivo evaluation slow progress in developing PSC-CM therapy to attenuate remodeling after injury.

Goal(s): To determine whether matured PSC-CMs improve ventricular function and scar integration using MRI biomarkers in a guinea pig model.

Approach: Cine and diffusion MRI measured function and structure in cell-treated versus sham-treated animals, allowing in vivo assessment of regional and global function changes.

Results: MRI revealed attenuated ventricular dilation and enhanced wall thickening in the scar region in treated animals, indicating functional integration of PSC-CMs.

Impact: This study demonstrates that MRI biomarkers can assess PSC-CM therapy efficacy in vivo, providing a tool to refine regenerative treatments. By enabling precise monitoring of therapeutic integration, this approach may guide optimization of future regenerative therapies toward clinical applications.

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