Abstract #1767

Cardiac contractility and ventricular efficiency are predictive of adverse cardiac remodeling independent of infarct size in STEMI patients

Theodor Lav¹, Thomas Engstrøm², Kasper Kyhl^2,3, David Nordlund¹, Jacob Lønborg², Henrik Engblom¹, David Erlinge⁴, and Håkan Arheden¹

¹Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden, ²Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, ³Department of Cardiology, Zealand University Hospital, Roskilde, Denmark, ⁴Cardiology, Department of Clinical Sciences Lund, Lund University and Skane University Hospital, Lund, Sweden

Synopsis

Keywords: Atherosclerosis, Diagnosis/Prediction, myocardial infarction, adverse remodeling, contractility, efficiency

Motivation: Current methods in clinical practice is unable to accurately predict adverse cardiac remodeling after ST-elevation myocardial infarction (STEMI).

Goal(s): To predict adverse cardiac remodeling in patients acutely after STEMI.

Approach: Applying non-invasive pressure-volume loop (PV-loop) variables by cardiovascular magnetic resonance (CMR) in STEMI-patients from The Third DANish Study of Optimal Acute Treatment of Patients with STEMI (DANAMI-3).

Results: Contractility and ventricular efficiency were predictive of adverse cardiac remodeling independent of age, sex, and infarct size.

Impact: Non-invasive PV-loops could be used early after STEMI in risk assessment for adverse cardiac remodeling.

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