Abstract #1770

The Correlation between Deep White Matter Hyperintensity and Hemodynamic Measurements of Perforating Arteries in Patients with CSVD

Tong Chen^1,2, Xun Pei^1,2, Xue Zhang^1,2, Yuanbin Zhao^1,2, Yuan Li³, Yingying Yang⁴, Yulu Shi⁴, Yilong Wang⁴, and Binbin Sui¹

¹Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China, ²Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing, China, ³MR Research Collaboration Team, Siemens Healthineers, Beijing, China, ⁴Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Synopsis

Keywords: Blood Vessels, High-Field MRI, cerebral small vessel disease, white matter hyperintensity, pulsatility index, penetrating artery

Motivation: The correlation between the severity of deep white matter hyperintensity (DWMH) and the hemodynamic measurements of the penetrating arteries remains unclear.

Goal(s): To investigate the correlation between hemodynamic measurements in perforating arteries and DWMH using phase-contrast-MRI (PC-MRI) on 7.0 T MRI.

Approach: The blood flow velocity and pulsatility index of perforating arteries were assessed by using PC-MRI. The correlations between hemodynamic measurements in perforating arteries and DWMH were analyzed.

Results: The pulsatility index of the perforating artery was positively correlated with the DWMH scores. The maximum blood flow velocity of the perforating artery was negatively correlated with the DWMH scores.

Impact: Understanding the correlations between the hemodynamic measurements of the perforating arteries and the severity of DWMH may help to further understand the mechanism of cerebral white matter hypersensitivity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.