Meeting Banner
Abstract #1777

Risk factors for the progression of white matter hyperintensity (WMH) in the patients with small vessel disease (CSVD)– A UK Biobank study

Xu Han1, Ying Hu1, Xiyao Gu2, Xiao Yu3, and Yan Zhou1
1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong Universit, shanghai, China, 2Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong Universit, shanghai, China, 3Clinical and Technical Support, Philips Healthcare, shanghai, China

Synopsis

Keywords: Blood Vessels, Diagnosis/Prediction

Motivation: White matter hyperintensity (WMH) is a key magnetic resonance imaging (MRI) marker of cerebral small-vessel disease (CSVD). These lesions disrupt specific fiber tracts and ultimately lead to cognitive decline.

Goal(s): Investigating risk factors related to the progression of WMH in CSVD patients, building a predictive model based on both clinical and imaging factors.

Approach: The associations between WMH growth rate and clinical features, MRI diffusion metrics were evaluated.

Results: Significant differences in glucose levels, age, and sex were observed between growth and shrinking group. Higher WMH growth rates were associated with lower whole-brain mean FA/ICVF but higher MD/ISOVF at baseline.

Impact: Our study highlights intricate relationships between clinical factors, imaging markers, and WMH progression.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords