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Abstract #1781

Association Analysis of Systemic Inflammatory Response Index with Cerebral Small Vessel Disease and Imaging Biomarkers

Ting Zhuang1, Lu Han2, Yongjun Cheng2, and Yuqin Zhang1
1Ningbo Medical Center LiHuiLi Hospital, Ningbo, China, 2Philips Healthcare, Shanghai, China

Synopsis

Keywords: Biomarkers, biomarkers

Motivation: CSVD (Cerebral Small Vessel Disease) refers to a range of pathological processes that affect the small blood vessels in the brain, and is a major cause of stroke, cognitive decline, and dementia.

Goal(s): This study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and Cerebral Small Vessel Disease (CSVD), as well as common imaging biomarkers.

Approach: Univariate and multivariate logistic regression analyses were used to examine the relationship between SIRI and CSVD, along with WMH, lacunes, PVS, and RSSI.

Results: Results indicated that SIRI levels were independently associated with overall CSVD occurrence, moderate-to-severe WMH, lacunes, and RSSI.

Impact: These findings suggest that SIRI may serve as an inflammatory marker involved in CSVD development.

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