Abstract #1785

Ultra-high Resolution in vivo 7T MRI Detects Hippocampal Subfield Iron in Mild Cognitive Impairment and Alzheimer’s Disease

Reese Dunne¹, Hossein Moein Taghavi², Phil DiGiacomo³, Julian Maclaren², Meghan Bell², Mackenzie Carlson³, Elizabeth Mormino⁴, Victor Henderson⁴, Pascal Spincemaille⁵, Hangwei Zhuang⁵, Yi Wang⁵, Brian Rutt², Marios Georgiadis², and Michael Zeineh²

¹Mechanical Engineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Bioengineering, Stanford University, Stanford, CA, United States, ⁴Neurology, Stanford University, Stanford, CA, United States, ⁵Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Quantitative Susceptibility mapping, Alzheimer's disease, iron, hippocampus, 7T MRI, R2*, source separation

Motivation: Iron dysregulation and deposition may play a role in neurodegeneration in Alzheimer’s disease (AD), but limited studies have pushed the boundaries of MRI resolution to accurately quantify iron, particularly in the hippocampus.

Goal(s): Utilize ultra-high resolution MRI and QSM for quantitative analysis of hippocampal subfield iron deposition to investigate the role of brain iron in AD.

Approach: We acquired 7T multi-echo gradient echo MRI on 19 living human subjects (healthy, mild cognitive impairment, AD) to detect hippocampal source-separated QSM/R2* abnormalities and quantify iron concentrations within hippocampal subfields.

Results: Increased R2* and QSM-χ⁺ was detected in the subiculum-CA1 hippocampal subfields with worsening disease status.

Impact: This study successfully performed in vivo ultra-high resolution MRI to quantify iron deposition in hippocampi of MCI and AD patients, contributing to the development of iron as a neuroimaging biomarker for AD.

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