Abstract #1793

Relationship between brain oxygen metabolism and cognition in older adults

Jiani Wu¹, Kumiko Oishi², Anja Soldan³, Corinne Pettigrew³, Zixuan Lin², Yuxin Zhu³, Dengrong Jiang², Xin Li², Abhay Moghekar³, Peiying Liu^2,4, Kenichi Oishi², Marilyn Albert³, and Hanzhang Lu^1,2,5

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: A reduction in brain metabolism is a hallmark of neurodegeneration in Alzheimer’s disease (AD), according to recent criteria for staging AD. However, alterations in brain metabolism during the preclinical phase of AD are not fully understood.

Goal(s): To investigate the association between brain metabolism and cognitive performance at a very early stage of dementia, when cognition is still normal.

Approach: Using non-invasive MRI, we measured cerebral metabolic rate of oxygen (CMRO₂) and examined its association with cognitive test scores.

Results: CMRO₂ was lower in participants with MCI/dementia compared to those cognitively unimpaired. However, among the unimpaired group, CMRO₂ was inversely associated with cognition.

Impact: The present work suggests that, at the very early stage of Alzheimer’s disease, higher brain oxygen metabolism is a sign of lower cognitive function, reflecting brain's hypermetabolism/hyperactivity during preclinical neurodegeneration.

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