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Abstract #1802

Assessing liver function and liver fibrosis with the dual-input dual-compartmental uptake and efflux model based on DCE-MRI: a rat model study

Yiwan Guo1, Tingting Guo1, Peng Sun2, Ziwei Jin1, Fan Yang1, and Xin Li1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Clinical & Technical Support, Philips Healthcare, Wuhan, China

Synopsis

Keywords: Biomarkers, biomarkers, liver fibrosis, liver function, pharmacokinetic model

Motivation: Quantitatively assessing liver function and liver fibrosis is important for patients with chronic liver disease.

Goal(s): To evaluate the value of pharmacokinetic parameters derived from the dual-input dual-compartmental uptake and efflux model based on DCE-MRI for quantitatively assessing the liver function and liver fibrosis in a rat model.

Approach: The relationships between pharmacokinetic parameters and the expression of hepatic transporters and histopathological metrics (Sirius red and α-SMA-positive ratios) were analysed in a liver fibrosis rat model.

Results: Significant correlations were found between pharmacokinetic parameters and the expression of hepatic transporters. The diagnostic efficency of these parameters for staging liver fibrosis was satisfactory.

Impact: Our findings suggested that the parameters derived from the dual-input dual-compartmental uptake and efflux model were useful for assessing liver function and simultaneously evaluating the degree of liver fibrosis.

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Keywords