Abstract #1804

Verification of redox and pyruvate metabolic changes using hyperpolarized MRI in early alcohol-related liver disease model mice

Tetsuro Kaga¹, Fuminori Hyodo², Abdelazim Elsayed Elhelaly^3,4, Yoshifumi Noda¹, Hiroki Kato¹, and Masayuki Matsuo^1,5

¹Department of Radiology, Gifu university, Gifu city, Japan, ²Department of Pharmacology, Gifu university Graduate School of Medicine, Gifu city, Japan, ³Department of Radiology, Frontier Science for imaging, Gifu university, Gifu city, Japan, ⁴Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt, ⁵Innovation Research Center for Quantum Medicine, Gifu University Graduate School of Medicine, Gifu city, Japan

Synopsis

Keywords: Preclinical Image Analysis, Hyperpolarized MR (Non-Gas)

Motivation: What metabolic changes occur in alcohol-associated liver disease (ALD)? Is it possible to detect reversible/irreversible points of fibrosis in ALD by hyperpolarized MRI?

Goal(s): To elucidate whether there are changes in redox metabolic activity and the metabolic activity of pyruvate to lactate in the early stage of ALD (eALD) model mice.

Approach: We visualized and evaluated these metabolic activities by using two types of hyperpolarized MRI.

Results: The redox metabolic activity might be decreased in the eALD mice compared to the control mice with NADH-deficient state. No difference was found in the metabolic activity of pyruvate to lactate in the eALD mice.

Impact: This study lays groundwork for the future investigations to detect reversible/irreversible points of fibrosis in chronic ALD using hyperpolarized MRI as an imaging marker.

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