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Abstract #1807

Evaluating Inflammation and Fibrosis Without Fat Influence in Metabolic Dysfunction-Associated Fatty Liver Disease: Pathological and Radiological Correlation in Rats

Kenichiro Okumura1, Naoki Ono2, Azusa Kitao1, Kazuto Kozaka1, XIAMIN SUN1, Hibiki Yamauchi3, and Satoshi Kobayashi1
1Department of radiology, Kanazawa University, Kanazawa, Japan, 2Faculty of Health Sciences, Institute Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 3Kanazawa University Hospital, Kanazawa, Japan

Synopsis

Keywords: Small Animals, Fat and Fat/Water Separation

Motivation: In metabolic dysfunction-associated fatty liver disease (MAFLD), fat, fibrosis, and inflammation coexist during disease progression. Therefore, MRI parameters, including fat-corrected T1, are needed to reflect inflammation and fibrosis.

Goal(s): To identify MRI images that accurately reflect inflammation and fibrosis, excluding fat.

Approach: Rats were fed a choline-deficient, L-amino acid-defined high-fat diet to induce MAFLD. We quantitatively compared MRI parameters with histopathological measures of whole liver fat, fibrosis, ferritin, and inflammation.

Results: Fat-corrected T1 values strongly correlated with fat, fibrosis, and inflammatory cells (CD45, CD68). Multiple linear regression revealed that fibrosis and inflammatory cells significantly affected fat-corrected T1 values, while fat did not.

Impact: In metabolic dysfunction-associated fatty liver disease, fat-corrected T₁ values vary in response to the levels of inflammation and fibrosis rather than fat. Therefore, fat-corrected T₁ values may be useful in distinguishing simple fatty liver from fatty hepatitis or predicting of prognosis.

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