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Abstract #1809

Simulcast X-nuclei Magnetic Resonance Imaging for Pathological Dynamics of Immune-Related Hepatitis in Rabbit

Kai Wang1, Chunsheng Yang1, Chuanxing Wu1, Jianmin Yuan2, Lingzhi Hu2, and Xilin Sun1
1NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC) of Harbin Medical University, Harbin, China, 2United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Biomarkers, Liver, Simulcast X-nuclei

Motivation: Immune-related hepatitis (IRH) is a serious side effect of tumor immunotherapy, often causing severe liver damage without early diagnostic markers. Conventional MRI is inadequate for early-stage detection.

Goal(s): To develop a simulcast X-nuclei MRI technique for early detection of IRH by monitoring microenvironmental changes such as hepatocyte edema, macrophage polarization, and metabolic shifts.

Approach: IRH was induced in rabbits, and simultaneous 1H/19F/23Na/31P MRI was conducted hourly to capture structural and metabolic changes. Blood and histological analysis validated imaging findings.

Results: 23Na MRI revealed hepatocyte edema, 31P MRSI indicated metabolic stress, dynamic 19F changes tracked macrophage activity, enabling real-time assessment of inflammation and injury.

Impact: This work highlights the potential of simulcast X-nuclei MRI in early detection and management of immune-related hepatitis.

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