Keywords: Small Animals, Quantitative Susceptibility mapping, iron deposition
Motivation: To investigate quantitative susceptibility mapping’s (QSM) potential in detecting iron deposition in renal fibrosis (RF) and iron deposition’s effect on QSM values in a rabbit model.
Goal(s): QSM can reliably detect longitudinal iron deposition in RF, offering a valuable complementary imaging marker for RF evaluation.
Approach: The dynamic changes of renal cortical and medullary signal with the progression of fibrosis were monitored by QSM, and the compensatory effect of the contralateral kidney was analyzed.
Results: QSM values of the renal cortex and medulla were moderately or strongly correlated with iron deposition in RF.
Impact: Different distributions of iron deposition between the cortex and medulla contribute to different QSM values, raising new possibilities in QSM applications for detecting iron deposition in RF. QSM offers a supplementary and promising imaging marker for evaluating RF.
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