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Abstract #1866

Respiratory-resolved lung oxygen and compliance mapping at 0.55T in patients with lymphangioleiomyomatosis

Joseph William Plummer1, Pierre Daudé1, Rajiv Ramasawmy1, Ahsan Javed1, Anastastia Tsakirellis1, Joel Moss2, and Adrienne Campbell-Washburn1
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, 2Critical Care Medicine and Pulmonary Branch, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Lung, Oxygenation, Oxygen enhancement

Motivation: Oxygen-enhanced (OE) pulmonary MRI and specific ventilation (SV) computation are two methods to assess regional lung function, however, they have yet to be acquired simultaneously and compared.

Goal(s): To develop a free-breathing technique that provides a respiratory-resolved OE and SV image simultaneously, to study oxygen perfusion and alveolar compliance abnormalities.

Approach: We implement (3mm)3 isotropic respiratory-resolved 4D imaging to calculate OE and SV maps at 6 phases throughout the respiratory cycle. We compare OE and SV heterogeneity between 7 healthy volunteers and 7 LAM patients.

Results: Respiratory-resolved OE and SV mapping show strong sensitivity to LAM-induced cysts. Both measurements were moderately correlated.

Impact: Respiratory-resolved oxygen-enhanced MRI offers a temporal view of pulmonary oxygen perfusion, complemented by additional insight into regional alveolar compliance from specific ventilation (SV) images calculated from the same data. This four-dimensional, patient-friendly approach enables comprehensive assessment of lung function abnormalities.

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