Abstract #1870

Free-breathing PREFUL-MRI of the lungs at 0.55T detects functional alterations in patients with lung lesions

Jia Liu¹, Wei Li¹, Xiang Wang¹, Jinxia Zhu², Xiaoye Wang³, Robert GRIMM⁴, and Jianxing Qiu¹

¹Peking University First Hospital, Beijing, China, ²MR Research Collaboration, Siemens Healthineers, Beijing, China, ³MR Clinical Marketing, Siemens Healthineers, Beijing, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany

Synopsis

Keywords: Lung, Low-Field MRI

Motivation: PREFUL-MRI offers assessment of lung ventilation function, providing guidance for treatment and follow-up.

Goal(s): To explore whether PREFUL-MRI of the lungs at 0.55T can detect functional alterations in patients with lung lesions.

Approach: Thirty-two patients with lung lesions were prospectively scanned in free-breathing mode using a TrueFisp sequence optimized for a 0.55T MR system before undergoing computed tomography-guided percutaneous lung mass aspiration biopsy. Pearson correlation coefficients were calculated to assess relationships between PREFUL-MRI-derived ventilation parameters and pulmonary function test results.

Results: Significant correlations were observed between PREFUL-MRI-derived ventilation parameters and pulmonary function test outcomes.

Impact: This exploratory study demonstrates the potential of free-breathing PREFUL-MRI at 0.55T in identifying functional abnormalities in patients with pulmonary lesions, suggesting its utility as a follow-up tool.

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