Meeting Banner
Abstract #1875

Direct imaging of pulmonary gas exchange in vivo with hyperpolarized xenon MRI

Hongchuang Li1,2, Haidong Li1,2, Ming Zhang1,2, Xiaoling Liu1,2, Yu Zheng1,2, Yuan Fang1, Yeqing Han1,2, and Xin Zhou1,2
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Wuhan, China, 2University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas)

Motivation: Hyperpolarized 129Xe gas MRI is a promising technique for assessing pulmonary abnormalities, yet distinguishing signals from RBCs and TP is challenging.

Goal(s): We aimed to develop a method to simultaneously image 129Xe in lung airspace and either TP or RBC for accurate gas exchange assessment.

Approach: Employing high selective RF pulses for selective excitation of 129Xe in TP and RBCs, while capturing lung airspace signals, and using a 3D radial sequence for acquisition.

Results: The method demonstrated feasibility in a rat model with pulmonary fibrosis, revealing significant differences in RBC/TP, RBC/Gas and TP/Gas ratios between fibrosis and control groups.

Impact: The proposed gas exchange MRI method improves diagnosis of lung diseases by accurately assessing gas exchange function in the lungs.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords