Keywords: Lung, Hyperpolarized MR (Gas)
Motivation: Hyperpolarized 129Xe gas MRI is a promising technique for assessing pulmonary abnormalities, yet distinguishing signals from RBCs and TP is challenging.
Goal(s): We aimed to develop a method to simultaneously image 129Xe in lung airspace and either TP or RBC for accurate gas exchange assessment.
Approach: Employing high selective RF pulses for selective excitation of 129Xe in TP and RBCs, while capturing lung airspace signals, and using a 3D radial sequence for acquisition.
Results: The method demonstrated feasibility in a rat model with pulmonary fibrosis, revealing significant differences in RBC/TP, RBC/Gas and TP/Gas ratios between fibrosis and control groups.
Impact: The proposed gas exchange MRI method improves diagnosis of lung diseases by accurately assessing gas exchange function in the lungs.
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