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Abstract #1877

Impact of inflation level on breath-hold 1H MRI surrogates of regional lung ventilation.

William C. Clark1,2, Joshua R. Astley1,2, Alberto M. Biancardi1,2, Laura C. Saunders1,2, Paul JC. Hughes1,2, Jim M. Wild1,2, and Bilal A. Tahir1,2
1POLARIS, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, 2Insigneo Institute, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Lung, Lung, 1H lung MRI, lung ventilation, functional lung imaging

Motivation: While breath-hold 1H-MRI ventilation surrogates require imaging at different inflation levels, the impact of inflation level selection on derived measurements remains unclear.

Goal(s): To evaluate the relationship between ventilation surrogates derived from different combinations of lung inflation levels (TLC, FRC+1L, RV) in healthy volunteers and patients with asthma and COVID-19 pneumonia.

Approach: Forty-seven subjects underwent breath-hold 1H-MRI at the aforementioned inflation levels. Ventilation surrogates were derived using deformable registration between paired inflation states and specific ventilation calculation.

Results: Strong correlation was observed between TLC-RV and FRC-RV surrogates (r=0.87), while other combinations showed markedly lower agreement (r=0.23-0.51).

Impact: This study demonstrates that breath-hold 1H-MRI ventilation surrogates vary significantly with inflation level. The strong agreement between measures derived from TLC-RV and FRC-RV suggests these combinations provide similar information, while other pairs may capture complementary aspects of regional ventilation distribution.

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Keywords