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Abstract #1884

Metabolic Shifts in Myocardial Recovery Post-CABG Assessed by Hyperpolarized-13C MRI

Gaurav Sharma1,2,3, Jaidip M. Jagtap4, Sarah McNeil1, Sung-Han Lin2, Crystal Harrison2, Jae Mo Park2, Matthias Peltz1, Craig R. Malloy2,5, and Michael E. Jessen1
1Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, United States, 4Radiology, Mayo Clinic, Rochester, MN, United States, 5Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Myocardium, Cardiovascular, Coronary Artery Disease (CAD), Coronary Artery Bypass Grafting (CABG), Hyperpolarized Carbon-13 MRI (HP-13C MRI) Myocardial Metabolism, Pyruvate Oxidation, Metabolic Recovery

Motivation: Coronary artery bypass grafting (CABG) is an effective treatment for severe coronary artery disease, yet its effects on effects on myocardial metabolic response remain poorly characterized.

Goal(s): To investigate post-CABG metabolic recovery by evaluating real-time pyruvate metabolism in CAD patients.

Approach: Hyperpolarized carbon-13 MRI (HP-13C MRI) was used to assess pre- and post-CABG myocardial metabolism in four CAD patients, comparing results with healthy controls to monitor pyruvate oxidation and metabolic recovery.

Results: Results indicate substantial variability in post-surgical metabolic recovery. While most patients displayed reduced pyruvate oxidation, one patient showed an improved bic/(bic+lac) ratio, suggesting diverse recovery pathways possibly influenced by substrate selection.

Impact: HP-13C MRI could guide personalized postoperative care, providing targeted metabolic insights that support optimized CAD patient management.

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Keywords