Keywords: Myocardium, Cardiovascular, Coronary Artery Disease (CAD), Coronary Artery Bypass Grafting (CABG), Hyperpolarized Carbon-13 MRI (HP-13C MRI) Myocardial Metabolism, Pyruvate Oxidation, Metabolic Recovery
Motivation: Coronary artery bypass grafting (CABG) is an effective treatment for severe coronary artery disease, yet its effects on effects on myocardial metabolic response remain poorly characterized.
Goal(s): To investigate post-CABG metabolic recovery by evaluating real-time pyruvate metabolism in CAD patients.
Approach: Hyperpolarized carbon-13 MRI (HP-13C MRI) was used to assess pre- and post-CABG myocardial metabolism in four CAD patients, comparing results with healthy controls to monitor pyruvate oxidation and metabolic recovery.
Results: Results indicate substantial variability in post-surgical metabolic recovery. While most patients displayed reduced pyruvate oxidation, one patient showed an improved bic/(bic+lac) ratio, suggesting diverse recovery pathways possibly influenced by substrate selection.
Impact: HP-13C MRI could guide personalized postoperative care, providing targeted metabolic insights that support optimized CAD patient management.
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