Abstract #1888

Left ventricular kinetic energy by 4D-flow CMR is unaffected in women 4–7 years after preeclampsia compared to after normotensive pregnancies

Cecilia Jönsson ¹, Karin Pola¹, Camilla Edvinsson², Stefan R. Hansson³, Per M. Arvidsson¹, Katarina Steding-Ehrenborg¹, and Erik Hedström⁴

¹Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Clinical Physiology, Skåne University Hospital, Lund, Sweden, ²Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, Sweden; Department of Anesthesia and Intensive care, Helsingborg hospital, Helsingborg, Sweden, ³Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, Sweden; Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Sweden, ⁴Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Clinical Physiology, Skåne University Hospital, Lund, Sweden; Diagnostic Radiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Radiology, Skåne University Hospital, Lund, Sweden, Lund, Sweden

Synopsis

Keywords: Flow, biomarkers, Preeclampsia, Kinetic energy

Motivation: Women with pregnancies complicated by preeclampsia have a higher risk for developing future cardiovascular disease compared to women with normotensive pregnancies. This indicates persistent cardiovascular changes, although the underlying mechanisms are still not clear.

Goal(s): Therefore, the aim of this study was to investigate how the heart adapts to prior preeclampsia by analyzing intracardiac blood flow.

Approach: Left ventricular kinetic energy calculated from 4D flow CMR imaging was compared between women with prior preeclampsia 4–7 years ago and women with normotensive pregnancies.

Results: Kinetic energy did not differ between the groups, suggesting limited clinical value of this biomarker.

Impact: Preeclampsia is a pregnancy complication with increased risk for cardiovascular disease. This study demonstrates that kinetic energy analysis of intracardiac blood flow, suggested as a new imaging biomarker of cardiac health, has limited clinical value after preeclampsia.

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