Abstract #1892

Noninvasive pulmonary arterial pressure measurement based on acceleration-encoding 4D flow MRI and Navier-Stokes equations

Zhaowei Rong¹, Xin Huang^2,3, Xiuhong Guan¹, Demao Deng⁴, Zhifeng Liu⁵, Hongyan Liu¹, Zehe Huang⁶, Chengwang Lei⁷, Rohan Dharmakumar⁸, Hairong Zheng⁹, and Guoxi Xie¹

¹School of Biomedical Engineering, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, ²Guangzhou Medical University & Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³SiemensShenzhen magnetic Resonance Ltd., Shenzhen, China, ⁴The People Hospital of Guangxi Zhuang Autonomous Region, Nanning, China, ⁵The Fouth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, ⁶The First People’s Hospital of Qinzhou, Qinzhou, China, ⁷Centre for Wind, Waves and Water, School of Civil Engineering, The University of Sydney, Sydney, Australia, ⁸The Krannert Cardiovascular Research Center, Indiana University, Indiana, USA, Indianapolis, IN, United States, ⁹Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Shenzhen, China

Synopsis

Keywords: Flow, Velocity & Flow, Acceleration & Flow

Motivation: Pulmonary hypertension (PH) is diagnosed as mean pulmonary arterial pressure (mPAP) greater than 20 mmHg by right heart catheterization (RHC). RHC is invasive, leading to delay in the diagnosis of PH.

Goal(s): To address this issue, we propose a novel method to noninvasively measure the mPAP based on an acceleration-encoding 4D flow MRI technique and Navier-Stokes equations.

Approach: The feasibility of the proposed method was tested and validated in a customized flow phantom, including 10 health volunteers and 2 suspected PH patients.

Results: Preliminary results indicate that the proposed method has great potential for noninvasively measuring the mPAP for the diagnosis of PH.

Impact: The proposed noninvasive method can be used to measure mPAP, enabling earlier diagnosis of PH. This advancement will prompt further research into noninvasive assessments of other cardiovascular conditions which require hemodynamic measurements.

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