Abstract #1905

Morphometric analysis of black bone MRI for radiation-induced bone injury in the head and neck

Natalie A. West^1,2, Lucas McCullum^1,2, Samuel Mulder^1,2, Travis Salzillo¹, Renjie He¹, Yao Ding³, Jihong Wang^2,3, Melissa Chen⁴, Stephen Y. Lai^1,2,5,6, and Clifton D. Fuller^1,2

¹Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, United States, ³Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁶Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Head & Neck/ENT, Radiotherapy, Cortical bone, toxicity, osteoradionecrosis, head and neck cancer

Motivation: To address the unmet need to accurately visualize cortical bone via current MR standard imaging methods.

Goal(s): To develop a morphometric analysis of black bone MRI; a low-flip angle sequence that captures cortical bone comparable to CT.

Approach: We obtained CT, T2-weighted, and black bone MRI scans from 15 head and neck cancer patients. Mandibles were manually segmented; dice similarity coefficient (DSC), mean distance to agreement (MDA), and volumetric analysis were evaluated. Wilcoxon signed-rank test checked for statistical significance.

Results: Black bone vs. T2-weighted MRI had improved DSC (0.868/0.722), MDA (0.0787/0.182), and volumetric accuracy (-3.95%/-9.37%) using CT as reference.

Impact: Black bone MRI shows promise in cortical bone visualization, which has direct potential to detect early anatomical changes caused by radiation. Its sub-millimeter voxel size allows for enhanced spatial resolution compared to standard-of-care CT and T2-weighted MRI.

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