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Abstract #1921

White matter hyperintensity iron overload mediates glymphatic system dysfunction and cognitive impairment in cerebral small vessel disease

Yage Qiu1, Yawen Sun1, and Yan Zhou1
1Department of Radiology, Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Neuroinflammation, Neuro, cerebral small vessel disease, quantitative susceptibility mapping, white matter hyperintensity , glymphatic system, mediation analysis

Motivation: The mechanism underlying the relationship between glymphatic system dysfunction and cognitive impairment in cerebral small vessel disease (CSVD) remains unclarified.

Goal(s): This study aimed to explore the role white matter hyperintensity (WMH) iron burden played in the pathogenesis of CSVD.

Approach: WMH iron burden was calculated using iterAtive magnetic suscePtibility sources sepARaTion QSM (APART-QSM), a sub-voxel quantitative method. Glymphatic system function was measured by DTI analysis ALong the Perivascular Space (DTI-ALPS) index. The relationships between WMH iron burden, DTI-ALPS index, and cognitive scores were examined through correlation and mediation analyses.

Results: WMH iron burden mediated DTI-ALPS index and cognitive score in CSVD.

Impact: Noninvasively, this study found WMH iron overload as a potential mediator in the relationship between glymphatic system dysfunction and cognitive impairment in CSVD, offering new insights for elucidating the pathological mechanisms underneath.

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