Keywords: Neuroinflammation, Neuro, cerebral small vessel disease, quantitative susceptibility mapping, white matter hyperintensity , glymphatic system, mediation analysis
Motivation: The mechanism underlying the relationship between glymphatic system dysfunction and cognitive impairment in cerebral small vessel disease (CSVD) remains unclarified.
Goal(s): This study aimed to explore the role white matter hyperintensity (WMH) iron burden played in the pathogenesis of CSVD.
Approach: WMH iron burden was calculated using iterAtive magnetic suscePtibility sources sepARaTion QSM (APART-QSM), a sub-voxel quantitative method. Glymphatic system function was measured by DTI analysis ALong the Perivascular Space (DTI-ALPS) index. The relationships between WMH iron burden, DTI-ALPS index, and cognitive scores were examined through correlation and mediation analyses.
Results: WMH iron burden mediated DTI-ALPS index and cognitive score in CSVD.
Impact: Noninvasively, this study found WMH iron overload as a potential mediator in the relationship between glymphatic system dysfunction and cognitive impairment in CSVD, offering new insights for elucidating the pathological mechanisms underneath.
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