Abstract #1931

T1ρ as a biomarker for IDH1 mutation status in a glioma mouse model

Hannah J. S. Ehler¹, Saki Sultana^2,3, Christa Davis³, Kimberly Brewer^1,2,3,4,5, and James Rioux^1,2,4,6

¹Department of Physics & Atmospheric Science, Dalhousie University, Halifax, NS, Canada, ²School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada, ³IWK Health Centre, Halifax, NS, Canada, ⁴Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ⁵Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada, ⁶Nova Scotia Health, Halifax, NS, Canada

Synopsis

Keywords: Biomarkers, Quantitative Imaging, Cancer; Molecular Imaging; Brain

Motivation: The aggressiveness of glioma depends on IDH mutation type, classification of which requires genetic analysis following a biopsy. This is an invasive procedure which can have lengthy wait times to receive results.

Goal(s): Explore quantitative T1ρ imaging as a noninvasive biomarker for IDH1 mutation typing in a glioma mouse model.

Approach: Mice with were implanted with IDH1-wildtype and IDH1-mutant glioma tumours and imaged weekly for five weeks with T1ρ and CEST as tumours developed.

Results: T1ρ can distinguish IDH1-mutant glioma from healthy brain tissue, whereas T1ρ values of IDH1-wildtype tumors are not significantly different from healthy brain.

Impact: T1ρ quantitative imaging shows promise as a noninvasive biomarker to determine IDH1 mutation status in glioma. Such a biomarker would allow faster classification, eliminating the wait time for biopsy results and potentially improving patient outcome through more personalized treatment.

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