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Abstract #1934

Multimodal imaging to assess treatment effect of a new therapy for glioblastoma in vivo

Mona Al-Gizawiy1, Robert Wujek2, Kyle Johnson2, Jason Sidabras1, Melissa Prah1, Jennifer Connelly3, Christopher Chitambar1,4, and Kathleen Schmainda1,5
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States, 3Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, 4Medicine, Medical College of Wisconsin, Milwaukee, WI, United States, 5Radiology, Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Keywords: Biology, Models, Methods, Multimodal, glioblastoma, MR spectroscopy, gallium, radiosensitizer

Motivation: Patients with treatment-resistant glioblastoma (GBM) have limited treatment options available to them.

Goal(s): We seek to develop an optimized imaging protocol to assess the treatment effect of the novel metallocompound, gallium maltolate (GaM) and evaluate in vivo its action as a radiosensitizer.

Approach: Our translational rat preclinical model utilizes MRI and MR spectroscopy to longitudinally monitor the treatment effect of GaM in combination with radiation therapy (RT).

Results: Combination therapy of GaM+RT in vivo results in a profound and sustained inhibition of established treatment-resistant GBM compared to monotherapy alone. This approach could dramatically change how brain tumors such as GBM are treated.

Impact: Our work seeks to shift current research and clinical practice paradigms by utilizing a novel and innovative therapeutic approach to target the iron metabolism of aggressive primary brain tumors for patients with limited treatment options.

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Keywords