Keywords: Biomarkers, biomarkers, cancer cachexia
Motivation: Cachexia is a devastating effect of cancer, which reduces the quality of life, ultimately leading to mortality. There is a dire need to develop sensitive non-invasive biomarkers to diagnose and monitor the effects of cachexia progression.
Goal(s): The goal of this study was to demonstrate a correlation between multi-parametric MRI (mpMRI) measures and atrophy biomarkers.
Approach: We scanned a genetically engineered KPC mouse model of pancreatic ductal adenocarcinoma using mpMRI, measures of physological function followed by histopathology, and polymerase chain reaction measurements.
Results: Our results showed significant correlations between MR parameters and specific atrophy biomarkers, demonstrating mpMRI provides valuable information on cachexia progression.
Impact: MR measures offer the potential to evaluate skeletal muscle fiber atrophy in preclinical models of pancreatic ductal adenocarcinoma and more impotantly these results can be translated to patients with cancer cachexia
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords