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Abstract #1949

Magnetic Resonance Molecular Imaging of Patient-Derived Xenografts with MT218

Ryan Hall1 and Zheng-Rong Lu1
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Biomarkers, Preclinical, Targeted contrast agent

Motivation: Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that often metastasizes early. Early and accurate diagnosis is imperative for improving TNBC patient management and survival.

Goal(s): We aim to evaluate MT218, an MRI contrast agent targeting extradomain-B fibronectin in the tumor extracellular matrix, in more clinically relevant small animal models.

Approach: Using NSG mice bearing TNBC PDX xenografts, we performed MRI of tumors after administration of MT218 at doses significantly lower than the clinical dose.

Results: Both low doses of MT218 demonstrated significant tumor-specific enhancement and facilitated the delineation of tumor boundaries for effective MRI of TNBC.

Impact: We demonstrate that MT218 can effectively enhance patient-derived xenograft tumors of triple negative breast cancer, a clinically relevant tumor model, further supporting the clinical translation of MT218 for magnetic resonance molecular imaging of cancer.

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Keywords