Keywords: Biology, Models, Methods, Cancer
Motivation: The Intraductal Papillary Neoplasm of the Bile Duct (IPNB) is a macroscopic and precancerous lesion typically characterized by papillary or villous proliferation within the bile ducts.
Goal(s): Our study aims to establish a scoring system to predict the benign and malignant degree of IPNB.
Approach: Nomogram model based on imaging and clinical features was used to predict the malignant potential of IPNB.
Results: The nomogram model achieved an AUC of 0.855 (95% CI: 0.801–0.908) in the training set (threshold: 0.431, sensitivity: 0.879, specificity: 0.745) and an AUC of 0.912 (95% CI: 0.846–0.977) in the testing set (threshold: 0.446, sensitivity: 0.974, specificity: 0.783).
Impact: The scoring system demonstrates high sensitivity and specificity in predicting IPNB malignancy. This scoring system, based on clinical data and imaging features, enables early IPNB screening and surgical planning.
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