Keywords: Breast, Cancer, Quantitative Imaging, Ultrafast, Kinetics, Gadoterate meglumine, DCE-MRI, high temporal resolution, diagnosis
Motivation: There is increasing interest in high temporal resolution imaging techniques in MRI breast for cancer detection.
Goal(s): Our goal was to evaluate clinical application of Gadoterate Meglumine in abbreviated DCE-MRI breast for cancer detection, focusing on quantitative analysis with ultrafast imaging.
Approach: We calculated quantitative pharmacokinetic parameters from ultrafast imaging for breast cancer detection.
Results: Ktrans had the highest diagnostic sensitivity (98.3% [95% CI: 91.1-100; p-value < 0.05]). A, A* α, AUC30 (initial area under contrast enhancement versus time curve over 30 seconds), and Ktrans have excellent power for cancer detection, with areas under ROC of 0.955, 0.962, 0.963, and 0.938, respectively.
Impact: Ultrafast imaging (3.5–4.6 seconds) yields benefit individuals with preserved diagnostic accuracy for breast cancer detection. Furthermore, lower signal enhancement of background parenchyma by using gadoterate meglumine may help for lesion detection in screening settings, particularly in young or premenopausal women.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords