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Abstract #1990

MRE-derived Tumor Stiffness as a Non-invasive Technique to Characterize Breast Tumors

Akhil Deavela1, Brandy Griffith2, Jeffrey Hawley2, Kristin Thompson1, and Arunark Kolipaka1
1The Ohio State University, Columbus, OH, United States, 2Wexner Medical Center, The Ohio State University, Columbus, OH, United States

Synopsis

Keywords: Cancer, Breast

Motivation: Breast tumors can be detected and characterized using biopsy and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); however, MR Elastography (MRE) offers a novel, non-invasive diagnostic approach with comparable sensitivity and specificity.

Goal(s): Validate the use of MRE to characterize breast tumors by comparing it with typical diagnostic techniques like histological grading and DCE-MRI.

Approach: MRE was performed on patients with known breast tumors to measure stiffness and characterize breast tumors, then statistical analysis was conducted to validate the characterization against histological grading and DCE-MRI.

Results: MRE-derived tumor stiffness was statistically significantly consistent with clinical grading and DCE-MRI characterization of tumors.

Impact: The statistically significant consistency between the non-invasive MRE-derived tumor stiffness and the current gold-standards of diagnosis, histological grading and DCE-MRI, means that breast tumor characterization through MRE is possible while maintaining sensitivity and specificity.

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Keywords