Meeting Banner
Abstract #2000

Prediction of response to targeted therapy in HER2-positive breast cancer using MR radiomics

Tsai-Ni Hung1, Chia-Fen Lee2, Wen-Pei Wu2, and Chia-Feng Lu1
1Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan

Synopsis

Keywords: Breast, Breast, HER2 positive breast cancer

Motivation: There is a need for non-invasive approaches to predict HER2-targeted therapy response in HER2-positive breast cancer patients. However, studies in this area remain limited.

Goal(s): This study assessed the ability of response prediction using radiomic features extracted from dynamic contrast enhancement (DCE) MRI.

Approach: Radiomic features were extracted from DCE images with and without subtraction from the baseline images to construct machine-learning classification models. Model performance was evaluated with ROC curves.

Results: Predictive models with combined radiomic features from raw and subtracted images demonstrated better performance with an AUC of 0.883 compared to models with features from either raw or subtracted images.

Impact: This study demonstrated that combining raw and subtracted dynamic contrast enhancement images could enhance response prediction to targeted therapy in HER2-positive breast cancer. Our findings can facilitate personalized treatment for breast cancer patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords