Abstract #2002

Early MRI markers of response to neoadjuvant endocrine therapy for patients with hormone receptor-positive/HER2-negative breast cancer

Natsuko Onishi¹, Wen Li¹, Jessica E Gibbs¹, Teffany Joy Bareng¹, Pouya Metanat¹, John Kornak², Rita A Mukhtar³, Kimberly M Ray¹, Bonnie N Joe¹, The I-SPY 2 Imaging Working Group⁴, The I-SPY 2 Investigator Network⁵, Laura J Esserman³, A. Jo Chien⁶, and Nola M Hylton¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, United States, ³Department of Surgery, University of California, San Francisco, San Francisco, CA, United States, ⁴University of California, San Francisco, San Francisco, CA, United States, ⁵Quantum Leap Healthcare Collaborative, San Francisco, CA, United States, ⁶Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Breast, Treatment Response

Motivation: Functional tumor volume (FTV) and background parenchymal enhancement (BPE) are potentially useful MRI markers for assessing HR+/HER2– breast cancer undergoing neoadjuvant endocrine treatment (NET).

Goal(s): We aimed to investigate the combined ability of FTV and BPE as early markers of treatment response to NET, defined by pre-surgery FTV.

Approach: We tested the performance of FTV and BPE available up to 3 weeks of treatment in predicting whether pre-surgery FTV is more than or less than 1.1 cc.

Results: Both early changes in FTV and BPE predicted pre-surgery FTV and may be more effective when used in combination.

Impact: Functional tumor volume (FTV) and background parenchymal enhancement (BPE) derived from baseline and 3-week MRI predicted the final FTV after neoadjuvant endocrine treatment (NET) for patients with HR+/HER2– breast cancer. These metrics may be non-invasive early markers for NET.

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