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Abstract #2007

Universal versus subject-specific parallel transmit pulses for inhomogeneous magnetization transfer at 7T

Michelle H. Lam1,2, Vincent Gras3, Marcus Couch2,4, Christopher D. Rowley5, and Christine L. Tardif1,2,6
1Biomedical Engineering, McGill University, Montreal, QC, Canada, 2McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada, 3University Paris-Saclay, CEA, CNRS, BAOBAB, Neurospin, Gif-sur-Yvette, France, 4Siemens Healthcare Limited, Montreal, QC, Canada, 5Physics and Astronomy, McMaster University, Hamilton, ON, Canada, 6Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Magnetization Transfer, Magnetization transfer

Motivation: B1+ inhomogeneity at 7T renders uniform magnetization transfer (MT) and inhomogeneous MT (ihMT) difficult. B1+ and saturation inhomogeneity can be significantly reduced using parallel transmission (pTx) technology and RF pulse design, as shown in previous applications in chemical exchange saturation transfer (CEST) and MT.

Goal(s): To evaluate the performance of subject-specific and universal pre-saturation pTx pulse design in MT and ihMT at 7T.

Approach: Used PASTEUR framework to explore pre-saturation pTx pulse design for single and dual off-resonance pre-saturation.

Results: 7T subject-specific and universal pTx pulses improved saturation homogeneity and reduced image non-uniformity in simulated ihMTR and MTR.

Impact: To enable high-resolution whole-brain ihMT imaging at 7T, we require dual and single off-resonance pulses that produce a spatially uniform saturation. Our simulations showed improved ihMT uniformity using subject-specific and universal pre-saturation pTx pulses to a range comparable to 3T.

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