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Abstract #2010

Quantitative Macromolecular Proton Fraction Imaging using Pulsed Spin-Lock

Qianxue Shan1, Ziqiang Yu1, Baiyan Jiang1,2, Qiuyi Shen1, Jian Hou1, Queenie Chan3, Winnie Chu1, Vincent Wong4, and Weitian Chen1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China, 2Illumination Medical Technology Limited, Hong Kong, China, 3Philips Healthcare, Hong Kong SAR, China, 4Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China

Synopsis

Keywords: Magnetization Transfer, Acquisition Methods

Motivation: MPF-SL is a promising technique for MPF mapping in vivo. But its SNR can be limited by the RF hardware constraints in certain applications.

Goal(s): We propose a pulsed spin-lock technique to address the hardware constrain from the RF amplifier in MPF mapping using spin-lock.

Approach: The proposed method is validated using Bloch-McConnell simulation, phantom and in vivo experiments.

Results: The proposed method significantly enhances the total spin-lock duration using standard hardware in a clinical MRI system, and the results demonstrate its insensitivity to the parameters of water pool. Furthermore, it achieves a higher SNR compared to conventional MPF-SL method.

Impact: The technical can improve SNR of MPF-SL under typical RF hardware constrain and provide more reliable and robust MPF mapping in vivo.

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Keywords