Keywords: Magnetization Transfer, Acquisition Methods
Motivation: MPF-SL is a promising technique for MPF mapping in vivo. But its SNR can be limited by the RF hardware constraints in certain applications.
Goal(s): We propose a pulsed spin-lock technique to address the hardware constrain from the RF amplifier in MPF mapping using spin-lock.
Approach: The proposed method is validated using Bloch-McConnell simulation, phantom and in vivo experiments.
Results: The proposed method significantly enhances the total spin-lock duration using standard hardware in a clinical MRI system, and the results demonstrate its insensitivity to the parameters of water pool. Furthermore, it achieves a higher SNR compared to conventional MPF-SL method.
Impact: The technical can improve SNR of MPF-SL under typical RF hardware constrain and provide more reliable and robust MPF mapping in vivo.
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