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Abstract #2014

Investigation on Water Dynamics in Cell Swelling

Seong-Min Kim1, Kyeongseon Min2, Jung Seung Lee3, and Jang-Yeon Park1,3
1Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, 2Department of Electrical and Computer Engineering, Laboratory for Imaging Science and Technology, Seoul, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Magnetization Transfer, biology, models, methods

Motivation: Water is essential for the functioning of cells.

Goal(s): This study investigates water dynamics involved in cell swelling, a common physiological cellular phenomenon, using MRI.

Approach: We measured magnetization transfer (MT) to evaluate changes in the free water pool under two cell swelling conditions: hypoosmotic stress and [K+] elevation.

Results: Results show that cell swelling leads to an increase in the free water pool within a voxel, diluting the intracellular space. Additionally, T2 increased more in response to hypotonic stress than to [K+] elevation in the same cell volume, probably due to the different degree of dilution in the intracellular space.

Impact: This study elucidates the water dyanmics associated with cell swelling using MRI, particualrly showing differences between two different mechanisms of cell swelling, which will contribute significantly to a better understanding of cell physiology and function.

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