Keywords: Magnetization Transfer, biology, models, methods
Motivation: Water is essential for the functioning of cells.
Goal(s): This study investigates water dynamics involved in cell swelling, a common physiological cellular phenomenon, using MRI.
Approach: We measured magnetization transfer (MT) to evaluate changes in the free water pool under two cell swelling conditions: hypoosmotic stress and [K+] elevation.
Results: Results show that cell swelling leads to an increase in the free water pool within a voxel, diluting the intracellular space. Additionally, T2 increased more in response to hypotonic stress than to [K+] elevation in the same cell volume, probably due to the different degree of dilution in the intracellular space.
Impact: This study elucidates the water dyanmics associated with cell swelling using MRI, particualrly showing differences between two different mechanisms of cell swelling, which will contribute significantly to a better understanding of cell physiology and function.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords