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Abstract #2016

Fat-suppressed ultrashort echo time magnetization transfer (UTE-MT) modeling via subtraction of fat-selective image

Soo Hyun Shin1, Arya Suprana1,2, James Lo1,2, Jiaji Wang1, David B. Berry3, Eric Y. Chang1,4, Jiang Du1,2,4, and Yajun Ma1
1Department of Radiology, UC San Diego, La Jolla, CA, United States, 2Department of Bioengineering, UC San Diego, La Jolla, CA, United States, 3Department of Orthopedic Surgery, UC San Diego, La Jolla, CA, United States, 4Radiology Service, VA San Diego Healthcare System, La Jolla, CA, United States

Synopsis

Keywords: Magnetization Transfer, Fat and Fat/Water Separation

Motivation: UTE-MT imaging has shown potential in probing the molecular composition and microenvironment of short-T2 tissues. Yet fat signals and chemical shift artifacts interfere with morphological contrast and UTE-MT measurements.

Goal(s): To establish a fat suppression method for accurate UTE-MT imaging.

Approach: We subtracted a fat-selective image from a series of MT-weighted UTE images of the knee to suppress fat signals before UTE-MT modeling.

Results: The subtraction of fat-selective image successfully suppressed the fat signal without significantly compromising UTE-MT measurement.

Impact: The fat-suppressed UTE-MT method shown in this study will improve the accuracy of quantifying molecular compositions of short-T2 tissues. This fat suppression method also has the potential to be applied to other UTE-based quantitative MR techniques.

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Keywords